Cannabis Learning Center

Endocannabinoid System

The body system that helps explain why cannabinoids matter.

Your body already has a cannabinoid system

The endocannabinoid system, often shortened to ECS, is a signaling system in the body. It includes naturally produced endocannabinoids, receptors, and enzymes that help regulate many processes. Cannabis compounds can interact with this system in different ways.

Basic parts

PartMeaning
EndocannabinoidsCannabinoid-like compounds made by the body.
ReceptorsSites in the body that cannabinoids can influence, including CB1 and CB2.
EnzymesProteins that help build up or break down endocannabinoids.
PhytocannabinoidsCannabinoids from plants, such as THC and CBD.

Why THC and CBD feel different

THC can directly activate cannabinoid receptors in ways that produce intoxication. CBD does not work the same way and is not considered intoxicating. That is why two cannabis products can both be “cannabinoid products” but feel very different.

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